Revealing the significance of early detection of chronic obstructive pulmonary disease: insights from healthy lung initiative data at COP27 conference (2024)

Background

Climate change poses a significant threat to respiratory health, exacerbating conditions like asthma, Chronic Obstructive Pulmonary Disease (COPD), and respiratory infections increasing morbidity and mortality indirectly through exposure to greenhouse gases. During the 27th Climate Change Conference (COP27), the Healthy Lung Initiative (HLI) for the early detection of COPD among smokers was launched in Egypt.

Objective

We aimed to detect the prevalence and predictors of confirmed COPD among smokers and assess physicians’ adherence to prescribing pulmonary function tests (PFTs) among the COP27 conference attendees.

Methods

This study utilized smokers’ data from the HLI, employing a cross-sectional design with an interview-based questionnaire, supplemented by spirometry for lung function evaluation. Participants, comprising Egyptian and non-Egyptian residents in Sharm El-Sheikh city, were provided with educational materials and encouraged to seek further evaluation from a pulmonologist.

Results

The HLI study, conducted from November 6th to 20th, 2022, involved 1133 participants, 90% (1047) of whom were smokers. Most smokers were males (96.3%) and Egyptians (98.6%), with half aged 30–39 and the majority starting smoking within the last 20 years. Despite common respiratory symptoms, 47% suffered from dyspnea on exertion,and only 4.3% have undergone lung function tests, suggesting a potential underdiagnosis of COPD. Most participants (82.6%) had an FEV1/FVC ratio > 70%, indicating no spirometry-confirmed COPD diagnosis, while 147 participants (17% of them) exhibited all three cardinal COPD symptoms simultaneously. Male gender and daily cigarette consumption were significant predictors for confirmed COPD, while age showed no significance in regression analyses.

Conclusion

The ongoing HLI focuses on early detection and education to combat smoking-related risks, particularly among middle-aged males, while also highlighting the need for comprehensive strategies to address the intersection of smoking and climate change.

Human health, particularly respiratory wellness, is in danger from climate change in several ways. It can directly trigger and worsen pre-existing respiratory diseases such as bronchial asthma, Chronic Obstructive Pulmonary Disease (COPD), rhinosinusitis, as well as respiratory tract infections (RTIs). Exposure to other risk factors, such as greenhouse gases, indirectly increases the morbidity and mortality of those individuals [1, 2]. Additionally, carbon dioxide (CO2) has a detrimental impact on air quality in a variety of ways, worsening heat waves, raising ozone levels, increasing air pollen and allergens, and causing forest fires, dust storms, and extreme weather events [3, 4]. Pollen season is extended, and air pollution is intensified due to global warming and elevated CO₂ levels. More toxins, carcinogens, pollen grains, respiratory irritants, and pollutants are produced during forest fires. Ozone promotes bronchial hyperresponsiveness and worsens inflammation in the bronchial epithelial cells. All these variables worsen disease conditions, raise Emergency Department (ED) visits, hospitalizations, and lower lung function [4].

Egypt contributes only 0.57% of the world’s greenhouse gas emissions, but the country suffers greatly from climate change, a serious public health concern. This issue is recognized as one of the 17 Sustainable Development Goals (SDGs) worldwide due to its profound impact on people’s social and physical well-being. Although there is no particular emission reduction or limitation target that must be met, the national plan includes greenhouse gas reduction strategies [5]. Egypt hosted the 27th climate change conference (COP27) in November 2022, in Sharm El-Sheikh. During the conference period, the Egyptian Ministry of Health and Population (MoHP) launched the Healthy Lung Initiative (HLI) for the early detection of COPD among conference attendees especially smokers as a side health event [6].

There is a direct relationship between cigarette consumption and climate change. Pollution and climate change are considered environmental stressors and smoking itself is a coping mechanism for stress [7]. The harmful effects of smoking on one’s health have been extensively studied and recorded, but the effects of tobacco on the environment are often neglected. Every year, six trillion cigarettes are produced with consumption of nearly 5.8 trillion cigarettes annually [8]. Global smoking rates are rising as a result of increased smoking in developing countries. The steps of growing, curing, and manufacturing tobacco are harmful to the environment. More than 70% of the environmental harm caused by the entire process is attributable to farming, watering, and fertilizing. More carbon emissions are caused by burning coal and wood during the curing step than by all other stages combined [9]. In Egypt, where tobacco use is on the rise, the tobacco industry’s expansion is notable, with the country scoring 64/100 on the tobacco industry interference index in 2021, ranking 52/80 countries [10]. Rising smoking rates in Egypt, at 22% in 2010, driven by familial and peer influence along with exposure to Western media, underscore the urgent need for improved tobacco control measures to prevent serious health problems like cardiovascular diseases and COPD, requiring better healthcare worker training and standardized mass media and school-based health education programs [11].

COPD arises from a triad of genetic predisposition (G), environmental factors (E), and time (T), collectively known as GETomics, which can harm the lungs and disrupt their natural growth and aging processes [12]. Tobacco smoking, responsible for over 70% of COPD cases in high-income countries and 30–40% in low- and middle-income countries, along with household air pollution, poses a significant risk. COPD, a leading cause of long-term disability and mortality worldwide, is exacerbated by challenges in accessing healthcare, while the tobacco industry’s aggressive targeting of new customers in low- and middle-income countries is expected to escalate the global burden of COPD [13]. Symptoms experienced by COPD patients including dyspnea, chronic cough, activity limitations, sputum production, recurrent infections, and exacerbations are considered alongside relevant risk factors for diagnosis. According to GOLD guidelines 2024, COPD diagnosis is confirmed through spirometry, where a post-bronchodilator forced expiratory ratio (FER) of less than 0.7 indicates airflow obstruction in smoker-symptomatic patients. This ratio is calculated by dividing the Forced Expiratory Volume in one second (FEV1) by the Forced Vital Capacity (FVC) [14].

COPD is frequently misdiagnosed, leading to inadequate treatment for many patients, despite its preventability and treatability. To combat this, both community-based screening and thorough assessment of risk factors like age and smoking history are crucial for early detection [15]. At the United Nations COP27 conference, HLI employed these methods, collecting medical histories and offering counseling services alongside spirometry testing. This initiative highlighted the importance of addressing smoking-related health risks. The study aimed to determine COPD prevalence among conference attendees and evaluate physicians’ adherence to requesting Pulmonary Function Tests (PFTs)for early screening.

Study design

This analysis utilized smokers’ data obtained from the HLI; a cross-sectional design using an interview-based questionnaire administered via a mobile application, with data collected by the interviewer. Additionally, spirometry is employed to evaluate lung function. Then participants were provided with educational materials and advised to seek further evaluation from a pulmonologist.

Data source

The data were extracted from the HLI database, which aggregates information from public places including hotels, markets, and locations where people gather. The initiative was launched as a health-focused adjunct event during COP27, held in Sharm El-Sheikh, Egypt, spanning from 6th to 20th November 2022. This initiative featured a case-finding component aimed at facilitating the early detection of diminished lung function, which serves as a significant predictor for COPD among smokers. It collected demographic information including gender, nationality, and age, as well as smoking history details such as current smoking status, duration of smoking, and daily cigarette consumption. Additionally, it documented respiratory symptoms like exertional dyspnea, significant sputum production, chronic cough not related to colds, and whether participants had undergone pulmonary function testing in the past. Spirometry (SpirOx Plus®) was utilized to assess participants’ pulmonary function, estimating the FEV1/FVC ratio following bronchodilation, and these values were then incorporated into the participants’ data documented in the application-based questionnaire.

Initiative study population

Egyptian and non-Egyptian residents in Sharm El-Sheikh city who were willing to participate in the study gave their verbal consent before being interviewed.

The following criteria were used to exclude individuals from participation in the study and undergoing PFTs:

1. 1.

   Participants under the age of 16 and those who declined to take part in the study.

2. 2.

   Individuals with acute respiratory or cardiovascular conditions.

3. 3.

   Participants who had undergone recent surgery or experienced recent injuries.

4. 4.

   Individuals with active respiratory infections.

5. 5.

   Participants who had undergone recent eye surgery or experienced recent eye injuries.

6. 6.

   Individuals with cognitive impairment or an inability to follow instructions.

7. 7.

   Any other conditions that could potentially interfere with the accurate assessment of pulmonary function during the tests.

Primary outcome

Evaluating the PFTs by measuring the FEV1/ FVC ratio after bronchodilation.

Secondary outcome

Assessment of COPD prevalence and risk factors [COPD confirmed diagnosis by FEV1/ FVC less than 70% after bronchodilation among smokers [14]], as well as assessing the adherence of their chest physicians to ordering PFTs as a tool of diagnosis.

Sample size and sampling

The sample size was calculated using epi info7.2. software for population survey sample size calculation, using COPD prevalence 10.2% [16], population that attended the COP27 conference was 30.000, 2% margin of error, at 95% level of confidence the minimum accepted sample size was rounded to 870 participants.

Statistical analysis

Descriptive statistics of the participant’s characteristics were presented as frequency and percentage, while PFTs data were represented as mean and standard deviation(SD). Chi-square (or Fischer exact test), and independent t-test were used for the comparison of the two groups.

Univariate and multivariate Logistic regression analyses were performed for the FEV1/FVC ratio including significant factors, identified in the bivariate analysis, to calculate adjusted and unadjusted odds ratio (OR) for each predictor. Data were analyzed using IBM SPSS [17], Version 25.

The total number of HLI participants was 1133, Supplementary Table S1. This analysis focused only on smokers, 1047 (90%). The majority of them were males and Egyptians (96.3%, and 98.6%, respectively). About half of the participants (47.9%) were aged 30–39 years old, more than two-thirds (72.8%) started smoking less than 20 years earlier, and 47.2% consumed 10–20 cigarettes per day. Regarding respiratory symptoms, dyspnea on exertion was mentioned by 47.5% of participants, 38.1% had sputum, and 26.8% had a cough without a cold. Only 4.3% were previously advised to perform lung function tests indicating the adherence of physicians to ordering PFTs for diagnosing COPD and/or its severity, Table1.

The mean FEV1%, FVC%, FEV1 /FVC% after bronchodilatation were 83.4%, 86.6%, 82.6%, Table2. The majority of participants (82.6%) had FEV1/FVC ratio > 70%, Not spirometry confirmed COPD diagnosis, Fig.1a. Approximately 17.4% of participants (182) exhibited the three cardinal symptoms of COPD together, whereas only 35 participants (3% of the total smokers) had a confirmed diagnosis through spirometry, as shown in Fig.1b and supplementary Table S3.

Gender, age, smoking years, and cigarette consumption per day were the statistically significant variables that affect lung function among smokers p = 0.009, 0.017, 0.015, 0.002, respectively, Table3. In addition, there was a significant negative correlation between age, smoking years, and cigarette consumption per day variables and lung function FEV1/FVC ratio (r = -0.113; -0.270; -0.255, p < 0.0001) respectively. Significant predictors for developing confirmed COPD were male gender, smoking years 20–30, 10–20, > 20–30, > 30 cigarettes intake daily [OR 8.32, 1.58, 1.67, 2.52, 2.39] respectively. After applying multivariate logistic regression to adjust the OR, the significant predictors were identified as gender and daily cigarette consumption, while age showed no significance in either univariate or multivariate regression analyses, Table4.

HLI was launched at COP27 and is still ongoing, with an analysis conducted for initial participants to underscore the importance of early detection, spotlighting adherence to PFTs and patient education, and convincing policymakers of the significance of this initiative. Our findings reveal that middle-aged males constitute the majority of smokers in Egypt, with nearly half experiencing dyspnea on exertion, which could significantly disrupt their daily activities during their most productive years. This aligns with the Woodruff et al. study, which observed that respiratory symptoms were present in 50% of current or former smokers with preserved pulmonary function. The average rate of respiratory exacerbations, as indicated by the COPD Assessment test (CAT score), among symptomatic smokers was notably higher compared to rates among asymptomatic current or former smokers and individuals who never smoked, suggesting a potential indication of underlying COPD [18]. Only a small fraction, 4.3%, of smokers underwent pulmonary function tests (PFTs), despite nearly two-thirds of them experiencing chronic respiratory symptoms. This discrepancy suggests a potential presence of undiagnosed COPD among smokers, even without confirmed spirometry results. These findings underscore the importance of further investigation for all smokers.

In our study, age did not emerge as a significant predictor for COPD development. However, the total number of smoking years and the number of cigarettes smoked per day, regardless of heavy smoking status, were significant factors. This finding is consistent with a recent study on a Spanish population, which included 8,819 individuals, 858 with COPD (FEV1/FVC < 70%) and 7,961 without. The study revealed that COPD risk increased with smoking duration, intensity, and lifetime tobacco consumption. Specifically, the risk increased for those with smoking durations of 50 years or more and smoking intensities of 39 cigarettes per day or more [19].

Moreover, the strong correlations between climate change and human behaviors, such as the prevalence of smoking and daily cigarette consumption, have become increasingly evident [20]. In our study, the percentage of adult participants who reported smoking 10–20 cigarettes per day at the 27th Conference of the Parties to the United Nations Framework Convention on Climate Change (UNFCCC) in Egypt was 47.2%. Smoking is considered a dual-edged risk because it may increase greenhouse gas emissions (CO₂) and increase heat [21], as well as increase the impact of diseases (bronchial asthma, COPD). Environmental exposures impacted by climate change, such as air pollution, pollen, and other aeroallergens that are more retained in a warm climate, may further impede lung function [4]. Additionally, smoking is linked to lung cancer according to earlier research [22]. From the HLI administrative report, we identified that smoking has a high statistically significant risk for developing obstructive lung disease (FEV1/FVC ratio less than 70%), even after adjusting for age, gender, smoking years, and amounts by performing binary logistic regression [ OR = 15.4; p = 0.012, R2 = 51%].

The possible health threat posed by climate change has received little attention from American healthcare professionals. However, according to the American College of Physicians and Surgeons and 13 other national medical colleges from around the world, the biggest danger to human health in the twenty-first century is climate change, particularly for people with chronic lung diseases [23]. For the 12million Americans who have COPD and other severe lung diseases, many aspects of climate change (increased heat, more intense weather events, and higher ozone levels) are more concerning. They also have a higher chance of dying as a consequence of climate change. Heat is associated with an increase in all-cause mortality, and heat waves particularly harm the elderly and those who have ongoing respiratory or cardiovascular conditions [24, 25]. For instance, during the 2006 heat wave in Portugal, for every 1°C rise in mean temperature, all-cause mortality rose by 2.7% and COPD incidence rose by 5.4%. Even greater rises in COPD morbidity were seen in women and people over 75 [26]. A more significant impact modifier is air temperature because it can change the chemical composition of particulate matter. The effects of temperature on sulfate, organic carbon, and elemental carbon are all favorable [27]. Smoking prevalence during hot climates which are environmental stressors has a greater percentage of smokers [20]. Because smoking temporarily relieves the stress of the cold, smoking rates may rise in cold climates, contributing to climate warming and increasing risks. More research is required.

Pharmacological and psychological interventions have shown efficacy in aiding smoking cessation in Egypt. Furthermore, understanding psychological, personal, and social factors influencing smoking cessation can aid in tailoring interventions. However, despite various tobacco control efforts and policies, further measures such as standardized health education programs and stricter legislation are needed to prevent the rising smoking rates and meet global tobacco reduction targets [11]. HLI is a significant step in Egypt’s developing anti-smoking campaign that made a clear link between cigarette smoking and lung cancer and encouraged smoking cessation and stricter tobacco controls. Egypt is one of the top smoking nations in the world [28]. Today, reduced rates of tobacco-related morbidity and mortality have proven the benefits of those efforts. António Guterres, the secretary-general of the UN, urged everyone to continue “the battle for climate justice and climate ambition.” He concluded, “We can and must win this battle for our survival [29].

Strengths of the study

This design provides valuable insights into the prevalence and predictors of COPD among smokers during the COP27 conference. The study included a diverse sample of participants attending the COP27 conference in Sharm El-Sheikh. This enhances the applicability of the study findings to a broader population with similar characteristics. The HLI employed an interview-based questionnaire and spirometry to collect data on various factors, including sociodemographic information, smoking history, respiratory symptoms, and pulmonary function tests. This comprehensive approach ensures a good assessment of COPD prevalence, predictors, and the adherence of physicians to ordering PFTs.

Study limitations

The study primarily focused on smokers and their association with COPD. The data on non-smokers was not reported, and the study did not provide an in-depth analysis of COPD prevalence and predictors among non-smokers. Longitudinal or interventional studies would be needed to determine the causal effects of smoking on COPD and the impact of early detection through PFTs.

°C:

Celsius

CI:

Confidence interval

CO2:

Carbon Dioxide

COP27:

27th climate change conference

COPD:

Chronic obstructive pulmonary disease

ED:

Emergency Department

FER (FEV1/FVC):

The forced expiratory volume in the first second to the forced vital capacity of the lungs

FER:

Forced expiratory ratio

FEV1:

Forced Expiratory Volume at the first second

FVC:

Forced Vital Capacity

HLI:

Healthy Lung Initiative

Max:

Maximum

Min:

Minimum

MoHP:

Egyptian Ministry of Health and Population

OR:

Odds ratio

P:

P-value

PFTs:

Pulmonary function tests

R2:

Coefficient of determination

RTIs:

Respiratory tract infections

SD:

Standard deviation

UN:

United Nations

UNFCCC:

United Nations Framework Convention on Climate

US:

United States

USA:

United States of America

We acknowledge:

Dr/ Hanan Takla, Director of El Salam Chest Center.

Dr/Hadeel Mohamed, Chest specialist, El Salam Chest Center.

Dr/ Mohamed Zakaria Awad, Director of Helwan Fever Hospital.

Dr/ Esraa Abdel Azim, Chest Specialist, Assuit Chest Hospital.

Dr/ Amr Mabrook, Chest specialist, Dekernis Chest Hospital.

Dr/ Sarah Fattah, Chest Specialist, Imbaba Chest Hospital.

Dr/ Iman Aboelsaad, Alexandria Clinical Research Administration, MoHP.

The authors wish to thank all participants who donated their time to participate in this study.

No funding.

Acknowledgment:

Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB).

Authors and Affiliations

1. Director of the General Administration of Chest Diseases, MoHP, Giza, Egypt

   Wagdy Amin

2. Department of Clinical Research, Maamora Chest Hospital, MoHP, Alexandria, Egypt

   Rasha Ashmawy,Sandy Sharaf&Sally Zeina

3. Department of Biomedical Informatics and Medical Statistics, Medical Research Institute, Alexandria University, Alexandria, Egypt

   Rasha Ashmawy,Esraa Abdellatif Hammouda&Nancy Mohamed

4. Clinical Research Department, El-Raml pediatric Hospital, Ministry of Health and Population, Alexandria, Egypt

   Esraa Abdellatif Hammouda

5. Department of Clinical Research, Kom-Elshokafa Chest Hospital, MoHP, Alexandria, Egypt

   Rewan Gamal

6. Tanta Chest Hospital, MoHP, Gharbyia, Egypt

   Dina Abu Hamr

7. Health Affairs, MoHP, Kafr Elsheikh, Egypt

   Heba Gebril

8. Chest Diseases Department, Dekernis Chest Hospital, MoHP, Dakahlia, Egypt

   Ola Alaa

9. Chest Diseases Department, Imbaba Chest Hospital, MoHP, Giza, Egypt

   Ussama Taha

10. General Administration of Curative Medicine, MoHP, Giza, Egypt

    Hazem El-Feel

Contributions

WA: conceptualization, methodology, Share in writing the manuscript, RA: conceptualization, methodology, data analysis, writing results section, SS, SZ, NM, RG, EAH: share in data management, Share in writing and reviewing the manuscript, proofreading. DAH, HG, OA, UT: material and data preparation, data extraction, HEF: conceptualization, supervision, reviewing.

Corresponding author

Correspondence to Esraa Abdellatif Hammouda.

Ethics approval and consent to participate

Review and approval of the protocol were obtained by the Ministry of Health and Population research ethics committee [Com. No/Dec. No: 8-2023/17]. Informed consent was obtained from all the study participants and a legal representative for illiterate and minor participants. This research was performed in accordance with relevant national guidelines and regulations.

Consent for publication

Not applicable.

Competing interests

The authors declare no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions